doi:10.1097/CAD.0000000000000211, Fallah M, Davoodvandi A, Nikmanzar S, et al. Cathy Wong is a nutritionist and wellness expert. When considering the use of herbal supplements, seek the advice of your doctor. Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity. Am J Gastroenterol. Unable to load your collection due to an error, Unable to load your delegates due to an error. However, few of these claims are supported by solid evidence. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. People have traditionally used milk thistle for problems with the liver and gallbladder . Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. https://www.wolterskluwercdi.com/facts-comparisons-online/. There's limited evidence, though, for the role of milk thistle in bone health. It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. People who have diabetes or endometriosis should check with a doctor before using milk thistle. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS-BDNF-TrkB Pathway. Its anti-inflammatory and antioxidant properties mean that it is possibly neuroprotective and could help prevent the decline in brain function you experience as you age (14, 15). Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. Natural Medicines website. In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). However, the evidence is conflicting. What Are the Risks of Taking Milk Thistle? Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. In: Textbook of Natural Medicine. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. What Is Complementary, Alternative, or Integrative Health? . Accessed Oct. 30, 2020. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. One human trial found it to work as well as fluoxetine to manage OCD symptoms. Large-scale, properly-designed studies are needed. Here are 10 of the best herbs for your liver, including benefits and. Milk thistle extract has a high amount of silymarin (between 6580%) that has been concentrated from the milk thistle plant. Some medications have been known to interact with milk thistle negatively. metabolic syndrome, depression, cardiovascular diseases and thalassemia, in addition to its photoprotective activity in in vitro tests and preclinical studies. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Milk thistle is currently used for the treatment of toxin-induced liver injury, for its inhibition of progressive hepatic fibrosis and the prevention of cirrhosis, for its antifibrogenic effects in alcohol-induced cirrhosis and for modulation of insulin resistance. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. This content does not have an Arabic version. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. . One study questioned the benefits of milk thistle for liver diseases. This article will explore the uses of milk thistle and research on its potential benefits. The benefits of milk thistle can be attributed to its anti-inflammatory and antioxidant effects. Historically, people have used milk thistle for liver disorders and gallbladder problems. The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. Questions? Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). Accessed Oct. 30, 2020. If you are a Mayo Clinic patient, this could Careers. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. eCollection 2022. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle is often promoted for its liver-protecting effects. Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). Copyright 1996-2023 Cerner Multum, Inc. A 2010 review by researchers found that black . Studies on cancer cell lines (done in the laboratory) have found that elements in milk thistle: Researchers also are looking at how milk thistle might complement traditional care and treatment in people diagnosed with gastrointestinal cancers. We comply with the HONcode standard for trustworthy health information. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Elsevier; 2021. https://www.clinicalkey.com. Psoriasis (Auckl). Milk thistle (Silybum marianum) is a plant traditionally used as a liver tonic. Accessibility information is beneficial, we may combine your email and website usage information with Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Milk thistle is often sold as an herbal supplement. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Here are 7 science-based benefits of milk thistle. Silymarin is believed to have antioxidant properties. Generic name: milk thistle [MILK-THIH-sull] Accessed Oct. 30, 2020. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This publication is not copyrighted and is in the public domain. Milk thistle can also be taken with cholesterol-lowering medications, like statins. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. Call 911 or seek help right away if you experience severe side effects from taking milk thistle. The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties (2, 3, 4). The best doses of milk thistle have not been established for any condition it may be used to treat. 2014;2014:941085. doi:10.1155/2014/941085. 2. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). The .gov means its official. Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). "It helps to clear out the toxins and nourish the organ," says Justice. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. *These statements have not been evaluated by the Food and Drug Administration. Some people may be allergic to milk thistle. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. Eur Endocrinol. Multiple Myeloma vs. Leukemia: What Are the Differences? 5th ed. Huberman: "Anything that reduces 5-alpha reductase is going to reduce DHT & maintain or extend the growth phase, the anagen phase, of hair growth. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. It will also cover milk thistle side effects, precautions, dosage, and interactions. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Do not use this product without medical advice if you are breast-feeding a baby. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Copyright 2017 Elsevier Inc. All rights reserved. 2015;26(5):475486. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles.

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